Business Daily Media

Men's Weekly

.

CK Life Sciences’ Investigational Cancer Vaccines Deliver Promising Results - New Preclinical Study Data to be Presented at the 2025 American Association for Cancer Research (AACR) Annual Meeting

HONG KONG SAR - Media OutReach Newswire - 22 April 2025 - CK Life Sciences Int'l., (Holdings) Inc. ("the Company") announced that the Company will be presenting new data from its cancer vaccine research pipeline at the 2025 American Association for Cancer Research (AACR) Annual Meeting in Chicago, USA.



The AACR Annual Meeting is a gathering central to the global cancer research community, bringing together scientists, clinicians, other healthcare professionals, survivors, patients and advocates every year to share the latest breakthroughs and developments in cancer science and medicine. Last year, the 2024 Annual Meeting attracted 23,000 in-person attendees and 6,700 online participants from 78 countries.

In recent years, CK Life Sciences has regularly participated at the AACR Annual Meeting. The 2025 Annual Meeting will be held from 25-30 April. At the event, CK Life Sciences will exhibit posters highlighting data from preclinical studies of investigational cancer vaccines programs targeting (i) PRAME (Preferentially Expressed Antigen in Melanoma), (ii) PD-L1 (programmed cell death ligand 1), (iii) B7-H3 (B7 homolog 3) and (iv) Claudin 6 proteins, respectively.

PRAME is a protein highly expressed in several cancers, including melanoma, liver cancer and leukemia.

PD-L1 is one of the most important immune checkpoint proteins that is highly expressed in cancer cells to block T cell activation in the tumour microenvironment.

B7-H3 is another immune checkpoint protein that modulates T cell responses and is often overexpressed in cancer.

Claudin 6 is a tight junction protein that regulates epithelial barrier integrity and is overexpressed in cancers like breast cancer, lung cancer and endometrial cancer, where it is associated with tumour progression and metastasis.

In addition, CK Life Sciences will be co-presenting with our research collaborator two posters showcasing our Artificial Intelligence (AI)-empowered platform for designing cancer vaccines.

"CK Life Sciences is pleased with the preclinical efficacy results of its investigational cancer vaccines targeting PRAME, PD-L1, B7-H3 and Claudin 6 proteins, and we hope to further advance the research & development of these and other cancer vaccines. We are also excited about the progress achieved in our efforts to develop an AI platform aimed at designing cancer vaccines that are more likely to be immunogenic and clinically effective," said Melvin Toh, Vice President and Chief Scientific Officer at CK Life Sciences.

Dr. Toh continued, "CK Life Sciences is determined to accelerate its R&D to benefit cancer patients. Currently, a number of therapeutic cancer vaccines are in clinical and discovery/preclinical research stages. Amongst them, seviprotimut-L, a cancer vaccine already in the final research stage, is being tested for the adjuvant treatment of stage IIB or IIC melanoma following definitive surgical resection.

DETAILS ON POSTER PRESENTATIONS:

  • Abstract 853: PDL1-PRAME dual antigen cancer vaccine inhibits melanoma growth in syngeneic mouse model and induces antigen-specific immune responses
Authors: Kin-Tak Chan, Hsin-Wei Chen, Pi-Hui Liang, You-Yu Lin, Tristan Zhang, Melvin Toh

Session Category: Clinical Research
Session Title: Vaccines and Cell Therapies
Session Date and Time: 4/27/2025 2:00 PM - 5:00 PM
Location: Poster Section 35
Poster Board Number: 9

  • Abstract 3533: Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model
Authors: Na Wang, Melvin Toh, Hong Wang

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM
Location: Poster Section 39
Poster Board Number: 9

  • Abstract 3536: Synergistic effects of combined PD-L1 and B7-H3 fusion protein vaccination in a mouse model of pancreatic cancer
Authors: Kenneth Nansheng Lin, Melvin Toh, Hong Wang

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM
Location: Poster Section 39
Poster Board Number: 12

  • Abstract 3538: The development of neoantigen-derived peptide vaccine driven by AI epitope design and computer assisted epitope enhancement
Authors: Chi Han Samson Li, Hong Wang, Kin Tak Chan, Genwei Zhang, Jiewen Du, Lipeng Lai, Melvin Toh

Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM
Location: Poster Section 39
Poster Board Number: 14

  • Abstract 3649: Artificial intelligence accelerates shared neoantigen peptide cancer vaccine development
Authors: Genwei Zhang, Jiewen Du, Xiangrui Gao, Zhenghui Wang, Qingxia Zhang, Tongren Liu, Dong Chen, Chi Han Samson Li, Kin Tak Chan, Hong Wang, Melvin Toh, Lipeng Lai

Session Category: Bioinformatics/ Computational Biology/ Systems Biology/ Convergent Science
Session Title: Artificial Intelligence and Machine Learning for Therapeutic Election and Discovery
Session Date and Time: 4/28/2025 2:00 PM - 5:00 PM
Location: Poster Section 45
Poster Board Number: 11

The full abstracts are available in the AACR Online Itinerary Planner, which can be accessed at: https://www.abstractsonline.com/pp8/#!/20273

DISCLAIMER
This press release may contain forward-looking statements regarding the Group’s research and development projects which may involve risks and uncertainties. Actual results may differ materially from expectations discussed in such forward-looking statements.
All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int'l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information.

Copyright ©2025 CK Life Sciences Int’l., (Holdings) Inc. All rights reserved.

Hashtag: #CKLifeSciences #CancerVaccines #R&D #Pharmaceutical #AmericanAssociationforCancerResearch #AACR #PRAME #PD-L1 #B7-H3 #Claudin6Proteins #Melanoma #AI

The issuer is solely responsible for the content of this announcement.

News from Asia

2025 "TOPAI International AI Ecosystem Frontier Private Salon" Successfully Held in Tokyo, Exploring New Opportunities for Global AI Industry Development

TOKYO, JAPAN - Media OutReach Newswire - 30 July 2025 - On July 29, the 2025 "TOPAI International AI Ecosystem Frontier Private Salon" co-hosted by "TOPAI" and the "Inspiration Island Incubator," ...

PERSOLKELLY Evolves into PERSOL, Strengthening Workforce Solutions for Australia’s Growth Sectors

MELBOURNE, AUSTRALIA - Media OutReach Newswire - 31 July 2025 - Asia Pacific's leading HR solutions provider, PERSOLKELLY, has officially rebranded as PERSOL, unifying its operations across 13 m...

AI-Driven Cyber Attacks and Supply Chain Vulnerabilities Escalate Risk Landscape in Australia, Aon Report Finds

SYDNEY, AUSTRALIA - Media OutReach Newswire - 31 July 2025 - Aon plc (NYSE: AON), a leading global professional services firm, has released the Australia-specific findings from its 2025 Cyber R...

Hong Kong-developed EXOTICA UMAMI [EX M] challenges century old cooking traditions with breakthrough flavour enhancement technology

Revolutionary Cooking Sauce Defies Culinary Logic: Frozen Chicken Rivals Fresh, Budget Beef Rivals Premium WagyuHONG KONG SAR - Media OutReach Newswire - 31 July 2025 - The revolutionary multifunc...

TDCX Group acquires SUPA to supercharge AI-enablement platform Chemin

Acquisition strengthens Chemin’s capabilities in complex AI data services amid global demand surgeSINGAPORE - Media OutReach Newswire - 20 June 2025 - TDCX Group, a leading provider of digital cu...

Asian Agri Hosts "Healthy and Smart Together" Initiative with Community Partners in Medan to Enhance Health and Literacy Awareness

SINGAPORE - Media OutReach Newswire - 31 July 2025 - Asian Agri, in collaboration with Tanoto Foundation, the Medan City Health Office, the Medan City Library and Archives Office and Puskesmas Bel...

Oriental Remedies Clinic Opens Fifth TCM Clinic in Punggol Coast Mall

SINGAPORE - Media OutReach Newswire - 31 July 2025 - Oriental Remedies Clinic, a Traditional Chinese Medicine (TCM) clinic chain in Singapore, has announced the opening of its new clinic in Punggo...

Cushman & Wakefield Announces Key Appointments Across Combined APAC & EMEA Business

HONG KONG SAR - Media OutReach Newswire - 31 July 2025 - Cushman & Wakefield has elevated three senior leaders to newly-created positions in its combined APAC & EMEA business. The two re...

As Singapore celebrates its 60th Birthday, Amex’s Shop Small Movement Rallies Around Local Businesses for the Sixth Year

SINGAPORE - Media OutReach Newswire - 31 July 2025 - American Express today announced the launch of the Shop Small movement for the sixth year in Singapore, part of its global flagship initiative ...

SeABank and AFS clarified matters related to the Charter Capital Transfer Agreement of Post and Telecommunication Finance Company Limited (PTF)

HA NOI, VIETNAM - Media OutReach Newswire - 31 July 2025 - Regarding the Charter Capital Transfer Agreement of Post and Telecommunication Finance Company Limited ("PTF") and the public announcemen...

Shop Small Returns to Back the Small Businesses Supporting Local Communities

The annual Shop Small movement by American Express is returning for its 13th year in Australia to galvanise support for the country’s vibrant smal...

Introducing Commerce, the New Parent Brand of BigCommerce, Feedonomics and Makeswift, Powering an AI-Driven Future

Commerce’s open, intelligent ecosystem connects the tools and systems that drive growth and empower businesses to unlock data potential and deliver ...

How better billing can boost performance and profits in uncertain times

Optimising your revenue management function will help you put your business on stronger footing. The fact that economic conditions are tricky i...

Small-Business Cash-Flow Playbook 2025

An educational guide to managing ATO debt, real-time super and growth finance in Australia’s new landscape Why ATO debt just became the most expe...

Landowners Offered $30,000 Per Year for Just 1 Hectare: The Rise of 5MW Battery Projects Across Australia

In a pivotal shift reshaping Australia’s renewable energy landscape, landowners in Queensland, New South Wales, and Victoria are being offered up ...

Major national security tech alliance launches with Aerologix a founding member

Australia’s leading drone intelligence pioneer bolsters sovereign tech power Australia’s leading aerial data and drone intelligence platform, Aer...

Sell by LayBy