Business Daily Media
Business Marketing

HKBU-led research develops novel drug delivery system for Gouteng compound for Alzheimer’s disease treatment

HONG KONG SAR - Media OutReach Newswire - 6 December 2023 - A research team led by Hong Kong Baptist University (HKBU) has developed a novel drug delivery system for Alzheimer's disease (AD).

The researchers have engineered exosomes, extracellular vesicles released by cells, to effectively carry the bioactive compound Corynoxine-B extracted from the Chinese herbal medicine Gouteng to the brain of mice with AD. As Corynoxine-B can induce autophagy, a process that maintains the health of cells, this new drug delivery system using exosomes can improve cognitive function and movement while reducing the symptoms of AD.

The research findings have been published in the international academic journal Nature-Signal Transduction and Targeted Therapy.

Bioactive compound of Gouteng can treat AD

AD is the most common type of dementia in which the brain cells degenerate and die, characterised by a build-up of amyloid-beta and phospho-tau protein in the brain, resulting in the decline of the brain's cognitive functions. Currently more than 55 million people worldwide are dementia patients. In Hong Kong more than 100,000 elderly suffer from dementia and the number is anticipated to soar to more than 330,000 by 2039.

At present there is no curative treatment for AD. Available treatments can only delay the disease's progression and improve symptoms. HKBU's previous research projects found that Corynoxine-B, a bioactive compound of Gouteng, is effective in treating AD. However, the blood-brain barrier which protects the brain from potentially harmful substances in the bloodstream affects its uptake in brain.

Exosomes serve as drug carriers

To tackle this problem, a research team comprising Professor Li Min, Associate Dean (Teaching and Learning) of Chinese Medicine, and Dr Ashok Iyaswamy, Research Assistant Professor of the Teaching and Research Division at the School of Chinese Medicine at HKBU, along with other local, mainland and overseas scientists, have developed a novel approach to deliver Corynoxine-B to the brain using exosomes.

Exosomes are extracellular vesicles released by cells which can transport molecules between cells like nanocarriers. Recent studies have shown that they could be utilised as vehicles for drug delivery. To examine whether exosomes are effective drug carriers for AD, the researchers manipulated the neuronal cells in mice to overexpress an adaptor protein Fe65 on the surface of exosomes released by these cells. Fe65 is involved in the processing of amyloid-beta precursor protein (APP), which plays a crucial role in the development of AD.

By doing so, they observed more exosomes containing Fe65 were released by the neuronal cells. These engineered exosomes showed a good ability to migrate towards the neuronal cells with APP overexpressed in AD models. These findings suggest that the presence of Fe65 on the surface of exosomes enhanced their ability to specifically target and interact with the neuronal cells with elevated levels of APP, which is a characteristic feature of AD.

Reduction of accumulated amyloid-beta protein

Corynoxine-B is a natural inducer of autophagy which plays a crucial role in maintaining neuronal health. The research team loaded it into the engineered exosomes and injected it to the mice with AD to evaluate its potential as a therapeutic agent for the disease. Results show that engineered exosomes loaded with Corynoxine-B could enhance autophagy in mice, and were able to cross the blood-brain barrier to deliver Corynoxine-B to the brain, resulting in a 30% reduction of accumulated amyloid-beta protein.

In addition, various behavioural tests including the rotarod test, open field test, contextual fear conditioning test, and Morris's water maze test conducted on mice with AD showed that the application of engineered exosomes loaded with Corynoxine-B resulted in 25% recovery of the cognitive and locomotor behaviour.

Professor Li Min said: "Our study suggests that exosomes could be a promising new way to deliver drugs to the brain and treat AD. More research is needed, but this study provides hope that a cure for AD may be possible in the future. We hope that this research project will ultimately be beneficial to the elderly, individuals at high risk of neurodegeneration and neurodegenerative disease patients."

Hashtag: #Alzheimer'sdisease

The issuer is solely responsible for the content of this announcement.

News from Asia

Best Places to Work Certification Celebrates Top Companies for Women in 2023

NEW YORK, LONDON, SINGAPORE - Media OutReach Newswire - 15 February 2024 - Best Places to Work, the leading certification program on workplace excellence, is thrilled to unveil the top 5 companies...

VinFast Partners with Five Dealers in Indonesia

JAKARTA, INDONESIA - Media OutReach Newswire - 16 February 2024 - At the Indonesia International Motor Show (IIMS) 2024, VinFast Auto officially signed the Letter of Intent with five dealers in...

Deleted

This Press release has been killed

Yuno announces Jonathan Hall as the new Asia-Pacific Head

Yuno, a leading global payment orchestration platform, appoints Jonathan Hall as Asia-Pacific Head, marking a new era in its expansion into other markets. SINGAPORE - Media OutReach Newswire - ...

Kriya Lightning Foundation Partners With Domestic Worker Communities to Launch Free Mental Wellbeing Improvement Program

HONG KONG SAR - Media OutReach Newswire - 19 February 2024 - Kriya Lightning Foundation announces the launch of its transformative "Self-Care Sundays" series, featuring free workshops for migrant ...

Citi appoints Joy Cheng as Head of Citi Commercial Bank for Hong Kong

HONG KONG SAR - Media OutReach Newswire - 19 February 2024 - Citi today announced the appointment of Joy Cheng as Head of Citi Commercial Bank (CCB) for Hong Kong, effective February 1, 2024...

Transamerica Life Bermuda launches Genesis II Indexed Universal Life insurance plan for wealth maximization and lifetime protection

The upgraded indexed universal life plan aims to empower HNW customers in building and enhancing multi-generational wealth with a wider choice of index account options, extended protection and new ...

K11 ARTUS plays host to Chow Yiu Fai as its fifth Artist In Residence

The Artisanal Home brings Lyricist and Scholar Chow Yiu Fai under its roof to inspire creativity. HONG KONG SAR - Media OutReach Newswire - 19 February 2024 - K11 ARTUS, through its programme, Art...

Melco Style Presents: The Black Pearl Diamond Restaurants Gastronomic Series to Commence the 2024 Events this March

Tickets for the Yí x Xujiacai, Bi Ying x Huaiyangfu, and Aurora x Amico BJ dinners in Macau to go on sale starting February 19 MACAO SAR - Media OutReach Newswire - 19 February 2024 - The acclaime...

2035 E-Mobility Taiwan: The Platform Shaping the Future of Mobility

TAIPEI, TAIWAN - Media OutReach Newswire - 19 February 2024 - 2035 E-Mobility Taiwan, Taiwan's foremost E-Mobility trade show, returns to Taipei from April 17 to 20 at Taipei Nangang Exhibition C...

Popular

Diolog launches world’s first two-way communications platform

Aussie entrepreneur Amy Benson is reinventing how companies communicate to better attract and retain investors      Diolog, the Australian technology company and creator of the world’s first two-way investor communications so...

Business leaders react to Treasurer Josh Frydenberg’s 2020 Federal Budget

Dr Benjamin Coorey, Archistar Founder & CEO “The R&D incentives initiative is a game changer for us because it provides the very thing that all start up businesses want - certainty. These changes are strongly supporte...

Private health insurance premiums are going up this week. But the reasons why just don’t stack up

Private health insurance premiums are set to rise on October 1, an increase companies have delayed for six months due to the COVID-19 pandemic. But 2020 has been a year like no other. And some of the reasons insur...

Virtual Office